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A study performed in mice supplemented nutritionally with 400 mg/kg/day of synthetic NR showed an increase in NAD + levels in muscle and liver tissue ( + /NADH ratio, it could be related to an improvement of the oxidative capacity of the mitochondrial pathway and could be a therapeutic strategy of interest in those diseases that are associated with mitochondrial dysfunction and OS such as neurodegenerative diseases ( + levels provides greater mitochondrial resistance against OS (Yang T