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FIGURE 1 Increasing evidence suggests that microbiota, specifically gut microbiota contributes to the drug metabolism (Li and Jia, 2013)

Thus, interference with a single glutamine metabolic pathway or one part of that may have minimal effects in treating AML

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Integrin signaling through elevated integrin 1 and 1 expression mediates cell adhesion to extracellular matrix, cell migration and proliferation, growth factor secretion, and cytoskeleton organization