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Assumptions were made about the involvement of encephalitis [17, 18] and medications used in the treatment protocol of COVID-19 such as steroids, chloroquine derivatives, and benzodiazepines [19]

4.3 Targeted therapeutic strategies in response to ERS It is well known that both the morphology of biomaterials and the UPR pathway can significantly affect the osteogenic differentiation of stem cells and controlling UPR-mediated osteogenic effects by modulating the surface morphology of biomaterials is expected to be an emerging therapeutic strategy (189, 190) ( Figure 2 )

When bromazepam was administered to rats, the corresponding mercapturate and 6-methylthiobromazepam were identified in the bile (Tateishi et al., 1978a)