This destruction impairs Sertoli cell function, leading to decreased inhibin B production and a subsequent loss of negative feedback on the anterior pituitary, resulting in markedly elevated follicle-stimulating hormone
On the other hand, exosomes from cells with reparative potential, such as bone marrow mesenchymal stem cells (MSCs) or amniotic epithelial cells, have been found to downregulate the pro-ferroptotic lipid metabolism enzyme ACSL4, or upregulate parallel anti-ferroptosis pathways like FSP1/GPX4, thereby attenuating ferroptosis and promoting cartilage repair (Wang Y
For example, a study of MTHFR polymorphism genotypes in colorectal cancer patients reported that the frequency of methylated Bcl-2 promoter was significantly higher in individuals with CC genotype than that of those with CT and TT genotypes, and a significant difference of C and T alleles distribution were observed between patients with methylated and unmethylated Bcl-2 promoter 35
Furthermore, through the inhibition of platelet activation and cerebral vessel thrombosis, NAC maintains cerebral microcirculation, a requirement for tissue repair following injury
