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Specifically, 2-Oxatricyclo [4.3.1.0(3,8)] decane and pulegone demonstrate blood-brain barrier (BBB) penetration

10.1016/j.celrep.2016.11.001 39 GaoR.PengX.PerryC.SunH.NtokouA.RyuC.et al (2021)

food Chem., 26: 1338-1343

Overall, the current view in animals is that the physiological role of mPGES-2s is related to the degradation of PGH 2 rather than to its isomerization into PGE 2