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TB4 (Thymosin Beta-4) is a naturally occurring peptide found throughout the body that regulates actin dynamics, recruits stem cells and progenitor cells to injury sites, reduces inflammation, and drives new blood vessel formation

Another option is mechanical stimulation therapy, based on the sensitivity of the Piezo1 channel to mechanical stimulation, specific physical therapy or mechanical stimulation can be developed to regulate the activity of microglia by altering the mechanical properties of the microenvironment in the CNS, thereby promoting the clearance of A plaques

Human Mol Genet 15(2):R244-252

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