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We note that several of the temporary C-codes have been replaced with permanent J-codes effective January 1, 2026

At this stage, the hematological defects are indistinguishable from those of folate deficiency and include megaloblastic anemia, characterized by macro-ovalocytic erythrocytes, abnormal red cell indices, and a low hemoglobin concentration (see Chapter 17, Sections 17.2.7 and 17.4)