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Although neutrophils rely on glycolysis to provide most of the energy required for their basic functions ( 2.1 Glucose metabolism Glucose is the major substance used to supply energy in neutrophils ( As progenitor myeloid cells differentiate into neutrophils, their main energy source shifts from oxidative phosphorylation (OXPHOS), which connects the tricarboxylic acid (TCA) cycle with the electron transport train in aerobic respiration, to glycolysis ( Figure 1 )

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