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Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice

2.4 Mediation of targeted therapy resistance Under the pressure of the selection of targeted drugs, tumor cells evade treatment through metabolic reprogramming ( Notably, this metabolic adaptation often coexists with and may be reinforced by the reactivation of oncogenic signaling pathways, which provide complementary survival signals under therapeutic pressure

Sadeghianmaryan et al., 2020)

lower left panel: blood vessels of heart tissue were shown, scale bar: 50 m) from various organ-specific Aldh2 KO mice listed in Table (a), representative of two independent experiments