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Given the ability of products especially aldehydes to diffuse readily and directly impair DNA, leading to tumorigenesis and a tumor-promoting environment, there is a critical need for further preclinical and clinical scrutiny to ascertain whether long-term cancer therapy promotes the formation of new lesions or pre-metastatic niches

The resulting culture served as an inoculum that was added to 250 ml of modified Sauton medium (pH 7.0) at a concentration of 10 5 10 6 cells/ml, containing (per liter): 0.5 g KH 2 PO 4

3a and Supplementary Data 2)

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