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doi: 10.3390/ijms222111864 89 KempJ

Avissar N, Ornt DB, Yagil Y, Horowitz S, Watkins RH, Kerl EA, et al

Biomedicine & Pharmacotherapy 2017, 96, 459465

Ravikumar et al., 2010) reveal abnormal cleavage of PICALM in AD brains, with significantly reduced 75 kDa PICALM levels, disrupted cathepsin D (Cath D) processing, and impaired lysosomal function, leading to autophagy deficits and inhibited Tau degradation