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The study also found that decursin exhibited intrinsic free radical scavenging capacity and activated Mitogen-activated protein kinase (MAPK) pathways, which in turn activated Nrf2 and produced heme oxygenases (HO-1), protecting PC12 cells from A2535-induced oxidative cytotoxicity

137 The brain has weak antioxidative defenses and a high oxygen consumption rate, making it particularly susceptible to OS

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