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Absorption of vitamin B 12 is inhibited from both dietary sources and from the bile (enterohepatic circulation) and thus depletion of vitamin B 12 body stores can occur relatively quickly

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doi:10.1016/j.annemergmed.2013.06.022 Mayo Clinic

Post hoc analyses of the British Isles Lupus Assessment Group (BILAG) index suggest modest benefit in mucocutaneous disease, particularly at higher doses