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Biochim Biophys Acta 16: 288289

Activation of astrocytic glutamate receptors was shown to translocate nuclear factor-erythroid 2-realted factor-2 (Nrf2) (present in lower concentrations in neurons) into the nucleus and to trigger the expression of antioxidant genes, notably related to glutathione metabolism (Jimenez-Blasco et al., 2+ waves (Nagai et al., Ascorbate is also another important antioxidant anion in the brain and glutamate was demonstrated to stimulate its release from astrocytes (Wilson et al., 2000), suggesting an essential protecting role of the ascorbate flux from astrocytes to neurons during synaptic activity (Acua et al., 6)

Sustained calorie restriction, particularly when dietary variety is limited, can lead to deficiencies in key micronutrients that play a direct role in maintaining normal cardiac rhythm

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