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283,284 Hyperglycemia activates NF-B signaling pathways, enhancing the expression of inflammatory genes and further amplifying the inflammatory response

These models were adjusted for age, BMI, age at menarche, hypertension diagnosis, type 2 diabetes diagnosis, history of cancer, smoking status, alcohol consumption, family history of cancer, postmenopausal status, and parity

Statistical analysis The statistical significance between multiple data sets was determined by one-way ANOVA

Notably, recent studies have shown that long-term diaphragm training with high resistance load could lead to diaphragmatic injury, especially in patients with advanced COPD(Louvaris et al., 2021)