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The research group was investigating synthetic -MSH analogs with improved pharmacological properties compared to native -MSH which suffers from rapid enzymatic degradation and limited biological activity due to structural instability

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Exchangeable Apos, sharing unique structure related to their biological functions, are soluble in aqueous solutions and transport between various lipoproteins depending on changes in lipoproteins size and lipids composition 29

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That pattern happens because multiple bottlenecks are being addressed together

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