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Endotoxins are lipopolysaccharides (LPS) from the cell walls of gram-negative bacteria that remain present even after bacteria are killed during sterilisationthey cannot be removed by standard filtration and provoke immune responses in biological systems

This shapes the entire dosing approach: you want enough to maximize receptor engagement, not more

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132 ng/mL or 298 nmol/L), which are based only on the prevention of anemia, is significantly lower than what is necessary for the prevention of this DNA damage, that is minimized in i.e