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Furthermore, the silencing of specific repair genes can directly result in drug failure at the biochemical level

In addition to air pollutants, numerous other pollutants, including microplastics, bisphenol A, heavy metals, and radiation, have been demonstrated to influence human health by regulating ferroptosis [7]

Only some differences between human and canine IVDs were found, such as the absence of growth plates in developing human vertebrae, thicker cartilaginous endplates and more pronounced endplate irregularities in humans with increasing severity of IVD degeneration [9]

Similarly, in a rat model of traumatic brain injury, progesterone has been described to promote angiogenic activity of endothelial progenitor cells (Yu et al., 2017)