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Corticosteroids are typically used for limited periods of time due to the risk of possible side effects

An ensemble model averaging the predicted probabilities from these four models achieved an AUC of 0.870, outperforming all individual models and the ABCD2 score (AUC, 0.713)

& Abramson, S

Historically, the obesity pharmacotherapy literature notes early trial signals and also that development was terminated after failure to show meaningful weight loss in a larger, longer trial (as summarized in a peer-reviewed review discussing a 12-week signal and a later 24-week negative result)