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Folate must be checked alongside B12, and folate deficiency should never be treated in isolation when B12 is low, because doing so can mask the anaemia while neurological damage progresses

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Unlike stimulant appetite suppressants like phentermine that induce stereotypic behaviors and head-weaving, tesofensine causes minimal stereotypy at therapeutic doses, indicating a more refined pharmacological profile with reduced central stimulation side effects while maintaining robust anti-obesity efficacy

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