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J Clin Invest 120(9):33773388

The effect of 4-methylpyrazole on oxidative metabolism of acetaminophen in human volunteers

286 This indicates that aging is accompanied by ROS accumulation, which is produced by the imbalance of oxidation and antioxidation

These findings suggest that MSG may increase cellular oxidative stress by suppressing the antioxidant defense system, and TA may significantly alleviate these adverse effects both at the gene level and in terms of enzyme activity, thus renormalizing the cellular redox level