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Abbreviations CP: Craniopharyngioma CO: Childhood-onset ACTH: Adrenocorticotropic hormone GH: Growth hormone GHD: Growth hormone deficiency IGF-1 : Insulin-like Growth Factor 1 ITT: Insulin tolerance test GHRH : Growth-hormone-releasing hormone GHRT: Growth hormone replacement therapy TSH : Thyroid-stimulating hormone GnRHa: Gonadotrophin-releasing hormone agonist CAI: Central adrenal insufficiency HPA: Hypothalamo-pituitary-adrenal MR-HC: Modified-release hydrocortisone ADH: Anti-diuretic hormone ADH-D: Anti-diuretic hormone deficiency DI: Diabetes insipidus HS: Hypothalamic syndrome POMC: Pro-opiomelanocortin BMI: Body mass index MRI: Magnetic resonance imaging HO: Hypothalamic obesity QoL: Quality of life -MSH : Alpha melanocyte-stimulating hormone SD: Sleep disorder EDS: Excessive daytime sleepiness SBD: Sleep-related breathing disorders OSAS: Obstructive sleep apnoea syndrome CRSWD: Circadian rhythm sleepwake disorders ICSD-3: International Classification of Sleep Disorders 3 PSQI: Pittsburgh Sleep Questionnaire Index MSLT: Multiple sleep latency test PAP: Positive air pressure IQ: Intelligence quotient DTI: Diffusion tissue imaging CV: Cardiovascular LDL: Low-density lipoprotein HDL: High-density lipoprotein BMD: Bone mineral density vBMD: Volumetric bone mineral density PEDQOL: Pediatric Quality of Life ZBI: Zarit Burden Interview HRQoL: Health-related quality of life References Muller HL

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If weight regain occurs or if appetite control becomes difficult, a clinician may prescribe Mounjaro or another GLP-1 medication to support further weight management