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This indicates that broad-spectrum antibiotics are not an ideal treatment, because they may have other undesired consequences, and long-term treatment may lead to the emergence of resistant bacteria (Velasquez et al., 2016)

Importantly, membrane-anchored FECH, which catalyzes the final step of heme biosynthesis, is known to bridge and physically interact with both ABCB7 and ABCB10 19,20