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Chronic low-grade inflammation, often called "inflammaging," is now recognized as a central driver of biological aging, contributing to cardiovascular disease, neurodegeneration, insulin resistance, and loss of muscle mass

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We found that, mechanistically, DON exposure blocks glycolysis and lactate production in porcine granulosa cells, reduces the level of H3K18la, inhibits the expression of STEAP3, leading to an increase in intracellular ferrous ions, thus inducing ferroptosis

In summary, GPR146 deficiency promotes a coordinated metabolic reprogramming of hepatic and systemic metabolism