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The interplay between multiple genes and their interaction with mitochondrial pathways or just mitochondrial genes may underlie the multifactorial nature of hEDS

R 2 is an amino acid selected from the group selected from the group consisting of tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine and valine

These results validate the gene expression differences associated with regional emphysema severity in independent cohorts from different clinical settings and support the hypothesis that the genes whose expression is associated with regional emphysema severity reflect the activity of true disease-associated processes