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This led to an increase in LC3-I, a decrease in the LC3-II/LC3-I ratio, and an increase in p62 (SQSTM1)

10.1053/gast.2000.16489 101 YustaB.HollandD.KoehlerJ

Targeted depletion of T cells and neutrophils attenuates this maladaptive immune activation, mitigates tubular injury and atrophy, and limits fibrosis progression, underscoring a central role for macrophage-driven T cell responses in perpetuating chronic inflammation [56]