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Transgenic Res

Roche et al., 2015)

Pregnancy and Breastfeeding: Limited but reassuring data suggests topical copper peptides at standard cosmetic concentrations are unlikely to pose risks during pregnancy or breastfeeding

As the negative arm, PER and CRY proteins heterodimerise to repress the transcription of BMAL1 and CLOCK, with the BMAL1/CLOCK and PER/CRY cycle taking ~24 hours