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220 A profile of 50 serum lipid metabolites, including phospholipids, sphingolipids, glycerophospholipid, and cholesterol esters, can distinguish COPD from healthy subjects: COPD can be considered a systemic hypometabolic state with reduced levels of Nacetylglycoprotein, lipoprotein, polyunsaturated fatty acid (pUFA), and lactate but with increased levels of diacylglycerols, branched chain amino acids, palmitoleic, oleic and linoleic acids

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Case 1 A young, healthy female patient aged 20 years reported to the department of conservative dentistry and endodontics with the chief complaint of dark spots on the gums, which looked esthetically unpleasant while smiling