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however, excessive production or insufficient clearance leads to oxidative and nitrosative stress, which can damage lipids, proteins, and nucleic acids

Ruiz-Ruiz, Moguel-Ordonez, Matus-Basto, & Segura-Campos, 2015)

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Upon exposure to mycotoxins or other stressors, Keap1 cysteine residues are modified, allowing Nrf2 to stabilize, translocate to the nucleus, and bind AREs