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Depression was measured using CES-D, which is not the gold standard clinical interview, while both chronic disease and CVD conditions were self-reported which could increase the risk of response bias

An imbalance in the intestinal barrier structure can flare up into an uncontrollable immune reaction in the intestinal microenvironment or allow the unrestrained growth of microbiota, which leads to various diseases, including intestinal inflammatory disorders, extra-intestinal autoimmune diseases such as rheumatoid arthritis and multiple sclerosis, and metabolic disorders such as diabetes and obesity 4,5,6

3 Division of Gastroenterology, Department of Medicine, Nanjing Medical University Nanjing First Hospital, Nanjing 210009, Peoples Republic of China

This is a common, but plausible statement to explain low in vitro-activities or salt sensitivities, because most of the antimicrobial peptides are produced for acting in short time intervals and after release from storage granules the peptides can locally reach remarkable high amounts as known from defensins [116]