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245 In all types of NCL, the CNS is significantly affected, resulting in varying degrees of neurodegeneration and associated symptoms

Recent advancements in the nano-encapsulation of curcumin have established a method to enhance its stability and solubility in aqueous environments, facilitating its delivery to various cellular compartments, particularly inner ear cells, that are primarily affected by cisplatin ototoxicity (Aggarwal and Sung 2009