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2011 PMC3120186 Hoyer, D

Melanin is not only the primary determinant of skin colour but also protects the skin against the damaging effects of UVR [1,2]

For instance, ESM1 overexpression in the MDA-MB-231 human breast cancer cell line and mice enhances angiogenesis via the upregulation of VEGF and d-like ligand 4 (DLL4, a ligand of Notch1 in the Notch signaling) (63)