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Results Reduced inflammation in Mda5 -/- HSCs and bone marrow serum Since activation of MDA5 induces a type-I IFN response and the secretion of pro-inflammatory cytokines, we isolated bone marrow serum from aged (18 to 24 months old) wild-type WT (or Mda5 +/+ hereafter WT) and Ifih1 -knockout mice (also known as Mda5