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Always apply broad-spectrum sunscreen, wear protective clothing, and limit direct sun exposure.Drug Interactions: Never take vitamin A supplements or tetracycline antibiotics while on isotretinoin, as this can lead to toxic interactions or increased pressure around the brain. Common Side EffectsMost side effects are manageable and reverse once the treatment course concludes:Severe Dryness: Chapped lips, dry skin, dry nose, and dry eyes are highly common

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Patients that experience claudication often exercise less which causes lower fluid shear stress, and regular intervals of high shear stress is known to promote healthy vasculature (263)