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Another multitarget MOR-DOR agonist, SRI-22141, was tested in the clinically relevant models of HIV neuropathy and chemotherapy-induced peripheral neuropathy, in which it was found that while providing equal or enhanced efficacy versus morphine, the tolerance was significantly reduced, with almost non-dependence during the course of repeated administration [59]

Long Noncoding RNA Profiling Revealed Differentially Expressed lncRNAs Associated With Disease Activity in PBMCs From Patients With Rheumatoid Arthritis

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Acta Oncol (2015) 54(9):132634