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mSystems 8 , e00532e00523 (2023)

These findings together with observed difference in microglia between the expression of ferroptosis-related genes in A-related versus tau-related pathology [18] suggests that vulnerability to ferroptosis might be related to both increased A aggregation and tau hyperphosphorylation

Key reports on ME/CFS have shown abnormal metabolites produced which demonstrate disturbed Amino Acid metabolism, dysregulated lipid metabolism with possible glycolysis impairment, possible Pyruvate Dehydrogenase (PDH) impairment, Urea Cycle dysregulation and overall TCA cycle substrates provision deficiency and reliance these cells for alternate fuel sources

Routes of Administration Studied in Research Preclinical research has evaluated BPC-157 via multiple administration routes, including subcutaneous injection, intramuscular injection, intraperitoneal delivery, and oral gavage