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The reverse cholesterol transport (RCT) pathway involving high-density lipoprotein (HDL) is an important process to maintain the balance of cholesterol metabolism, and promotes the efflux of free cholesterol from macrophages ( -/- mice and found that CD36 and SRA1 levels were increased in macrophages in TMAO-treated mice compared with control mice ( via a bile salt export pump (BSEP) and finally excreted with feces ( -/- mice ( Inflammatory response Atherosclerosis is also considered a chronic inflammatory disease because the endothelial inflammatory damage is ongoing throughout atherosclerosis progression ( in vitro studies of cultured endothelial progenitor cells (EPCs) by Chou et al