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Severino R, Ferrari G, Vu KD, Dons F, Salmieri S, Lacroix M

Wir wissen nichts zu Effektstrke, genaue Wirkung und ob es wirklich selektiv im Wunschgewebe aktiv ist

This work was supported by National Institutes of Health (R37CA240625 to KMA, R01CA259111 to KMA and NWS, T32GM133332 to ARC, R01CA242021 to NH, R35GM119512 to DTL), the American Cancer Society (RSG-19-113-01-CCG to KMA), the Ovarian Cancer Research Alliance (MIG-2023-2-1018 to AU), HERA Ovarian Cancer Foundation (AU), the Melanoma Research Foundation (RB), the Hollings Cancer Center Abney Graduate Fellowship (JAD), and the UPMC Hillman Cancer Center

This metabolic pathway is often hijacked by oncogenic drivers such as RAS and MYC, which enhance CHKA expression to meet the demands of rapid proliferation and membrane biogenesis (Kortlever et al., 2017)