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BPC 157 has strong angiogenic potential, it acts protectively on endothelium, prevents and reverses thrombus formation after abdominal aorta anastomosis, affects many central disturbances (i.e., dopamine and 5-HT system), the NO-system (either Larginine and L-NAME effects), endothelin, acts as a free radical scavenger (counteracting CCl4-, paracetamol-, diclofenac-injuries) and exhibits neuroprotective properties

The wider distribution of smaller nanoparticles in tissues was also reported for the delivery to tumors via the EPR effect, although the diffusion distance was shorter in that case because of the dense ECM network 46,47

Therefore, it is probable that TG2-mediated modification of GSTP1 affects the interactome of cellular GSTP1, resulting in an alteration of interactions with its binding partners

Our analysis showed that macrocyclic peptides were the most prevalent, accounting for more than half of the identified cyclic peptides, followed by bicyclic and polycyclic structures (see Figure 5A)