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Statements Author contributions XF: Writing original draft, Writing review & editing

Sensitivity analyses were conducted based on the etiology of cirrhosis

7), we emphasize that the ICV component served primarily as a preclinical proof-of-concept to validate direct CNS engagement for neural repair

When grouped by age and gender, female subjects at the age of 31-40 years had slightly higher NAD pool and GSH/GSSG ratios compared to 18-30 and 41-50 year-old females, respectively (Supplementary Figure 2j,s)