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Discovered in 1974 (Schoenenberger-Monnier group) from rabbit cerebral venous blood during induced sleep

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Reported reactions include: Reactive thrombocytosis Hypersensitivity: rash, pruritus, anaphylaxis Headache, paraesthesia, tremor Cardiac arrhythmias secondary to hypokalaemia Nausea, vomiting, diarrhoea Fever, chills, hot flushes, dizziness, malaise Injection site reactions: pain, erythema, pruritus, induration, swelling Acneiform and bullous eruptions Chromaturia (red/orange urine) Overdose Treatment is unlikely to be required