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Injury and inflammation to the pigmented layer of the retina (retinal pigment epithelium or RPE) as well as the choroid cause an altered and abnormal diffusion of nutrients to the retina and RPE, possibly precipitating further RPE and retinal damage (Zarbin 2004)

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c f , Immunoblot of NES-polyGAeGFP ( c ), FlagTDP-43-CTFeGFPNES ( d ), Flag-mEm-FUS-P525L ( e ) and Flag-SOD1-G93A-mNeo ( f ) in lysate fractions from HEK293T cells expressing HA or mPMLHA