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M1 phenotype One of two distinct functional states of polarized macrophage activation, the M1 macrophage subtype shows a 'pro-inflammatory' cytokine and chemokine profile

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Recent in vitro and in vivo studies show that numerous natural products (flavonoids, saponins, alkaloids, polysaccharide, phenylpropanoids, etc.) have specific antioxidant, anti-inflammatory, and anti-apoptotic properties that regulate the pathways associated with cisplatin-induced kidney damage