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Yi, X., et al

Its an FDA-approved injection used in people with type 2 diabetes

Our structures of Cagri-AMYR-G s complexes allow direct examination of the influence of a C-terminal proline in an amylin-template peptide through comparison of the interactions formed by P37 Cagri to that of Y37 rAmy with the CTR and AMYRs

GLP-1 Receptor Activation: Suppresses appetite through hypothalamic pathways Slows gastric emptying Enhances insulin secretion GIP Receptor Activation: Amplifies GLP-1 satiety effects Improves insulin sensitivity May directly affect fat cell metabolism Glucagon Receptor Activation: Increases energy expenditure (metabolic rate) Promotes fat breakdown (lipolysis) May prevent metabolic adaptation The Advantage: Single molecule means simpler manufacturing, potentially easier regulatory approval, and all three pathways activated with every dose