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Cells treated with ferroptosis inducers including RSL3 (Chemscene CS-5650), ML162 (Chemscene CS-0017910), FIN56 (Selleck Chemicals S8254)

Moreover, as the catalytic pockets of tyrosinases have been reported to exceedingly conserved across the diverse species 5 and mammalian tyrosinase crystal structure is not available yet, homology model of human tyrosinase (UniProtKB-P14679) was collected from AlphaFold database ( 39 and aligned with the 3D crystallographic structure of mushroom tyrosinase (mh-Tyr) using Superimpose tool in the Maestro v12.6 tool of Schrdinger suite-2020.4 40