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All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB)

10.4 How are peptides administered

And in the context of GH biology, overshooting carries consequences: IGF-1 excess has associations with insulin resistance, fluid retention, and in some populations, oncological risk

But here is the perspective piece: possible benefit is not the same as guaranteed effect, and hormone optimization is not the same as anti-aging proof. The Endocrine Societys review is clear that reversing age-related GH decline is not an approved therapeutic goal