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They also confirmed that concurrent treatment with JHU083 and anti-PD-1 checkpoint inhibitor improved the antitumor effects compared with anti-PD-1 treatment alone, suggesting the presence of metabolic plasticity between cancer cells and effector T cells, which could be exploited as a metabolic checkpoint for cancer immunotherapy 200

The authors suggest that serum IGF-1 facilitates brain A removal by enhancing the transport of A carrier proteins (e.g., transthyroxine, apolipoprotein J, and albumin) across the BBB, thereby improving choroid plexus barrier transport and increasing A efflux from the brain, thereby regulating brain A clearance [183, 185]

Therapeutically, targeting ferroptosis with rationally combined inhibitors, stimuli-responsive nanocarriers, and immunomodulators offers a promising precision strategy, provided that delivery systems are designed to tolerate the periodontal pocket environment

J Physiol (London) 117: 241250