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For example, in a murine model exposed to chronic hypoxia (10% O 2 ), the conditional deletion of HIF-2 in vascular cells (Wt1 lineage) resulted in cardiomegaly, ventricular hypertrophy, dilation, and systolic dysfunction, indicating that vascular signaling mediated by HIF-2 contributes to preserving cardiac homeostasis under chronic hypoxia [93]

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doi: 10.1158/1535-7163.MCT-07-0371 150 McAllisterSDMuraseRChristianRTLauDZielinskiAJAllisonJet al