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Feed-forward regulation between cellular senescence and immunosuppression promotes the aging process and age-related diseases

Free Radic Biol Med (2005) 38(12):154352

Yang Y, Lin Y, Wang M, Yuan K, Wang Q, Mu P

While the tyrosine kinase activity of IGF-1R is needed for downstream AKT activation, MAPK activation takes place without it (60), requiring in this case the C-terminal region of the receptor (61)