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It targets the parasite's cellular machinery, disrupting its metabolic processes and leading to its destruction

COMT and GSTM1/GSTT1 are functionally complementary both protect against 4-OHE2 quinone accumulation through different enzymatic mechanisms

Personal testament- traditional practice wont even look at giving HRT in pre-menopause

Finally, the functional redundancy or compensation between iron metabolic regulators in ferroptosis (e.g., whether inhibition of TFR1 can be rescued by enhanced ferritinophagy) has not been rigorously evaluated, which is essential for designing robust therapeutic strategies targeting iron-dependent ferroptosis